Abstract
Dagda et al. showed in this issue that cytosolic PINK1 released from the mitochondrion promotes dendritic outgrowth. This neurite-promoting activity of PINK1 is associated with the kinase activities of protein kinase A and is impaired by a pathogenic mutation in PINK1. The study by Dagda et al. has unravelled a novel mechanism underlying neurodegeneration caused by PINK1 mutation.
Publication types
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Editorial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Dendrites / physiology*
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Female
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Humans
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Male
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Mitochondria / metabolism*
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Pregnancy
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Protein Kinases / metabolism*
Substances
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Protein Kinases
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PTEN-induced putative kinase
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Cyclic AMP-Dependent Protein Kinases