Transmembrane molecular transport through nanopores formed by protein nanotubes

Chem Commun (Camb). 2014 Jan 18;50(5):602-4. doi: 10.1039/c3cc45907a. Epub 2013 Nov 26.

Abstract

Protein nanotubes formed by layer-by-layer (LbL) assembly can penetrate cells and act as nanopores for direct transmembrane delivery of chemical compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescein-5-isothiocyanate / chemistry
  • HeLa Cells
  • Humans
  • Microscopy, Confocal
  • Nanopores*
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Peptides / chemistry
  • Peptides / metabolism
  • Polyglutamic Acid / chemistry
  • Polyglutamic Acid / metabolism
  • Propidium / chemistry
  • Proteins / chemistry*
  • Proteins / metabolism

Substances

  • Peptides
  • Proteins
  • polyarginine
  • Polyglutamic Acid
  • Propidium
  • Fluorescein-5-isothiocyanate