CLL/SLL diagnosed in an adolescent

Marlise Luskin; Gerald Wertheim; Jennifer Morrissette; Robert Daber; Jaclyn Biegel; Donna Wilmoth; Leslie Kersun; Rebecca King; Michele Paessler; Cara Simon; Richard Aplenc; Alison Loren

doi:10.1002/pbc.24884

CLL/SLL diagnosed in an adolescent

Pediatr Blood Cancer. 2014 Jun;61(6):1107-10. doi: 10.1002/pbc.24884. Epub 2013 Nov 26.

Authors

Marlise Luskin¹, Gerald Wertheim, Jennifer Morrissette, Robert Daber, Jaclyn Biegel, Donna Wilmoth, Leslie Kersun, Rebecca King, Michele Paessler, Cara Simon, Richard Aplenc, Alison Loren

Affiliation

¹ Division of Hematology/Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

PMID: 24281971
DOI: 10.1002/pbc.24884

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a disease of older adults. Pediatric CLL/SLL is vanishingly rare in the literature. We present a case of CLL/SLL diagnosed in a 17-year-old male. The pathologic findings of this case were those of classic CLL/SLL with an ATM deletion, a characteristic genetic abnormality in CLL/SLL. Management guidelines for CLL/SLL are tailored to older adults making determination of the optimal therapy for this patient a unique challenge.

Keywords: cancer genetics; non-Hodgkin lymphoma; rare tumors.

Publication types

Case Reports

MeSH terms

Adolescent
Age Factors
Ataxia Telangiectasia Mutated Proteins / genetics
Biomarkers, Tumor
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 11 / ultrastructure
Chromosomes, Human, Pair 8 / genetics
Chromosomes, Human, Pair 8 / ultrastructure
Diagnostic Imaging
Gene Dosage
Genes, myc
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis*
Leukemia, Lymphocytic, Chronic, B-Cell / epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell / genetics
Lymph Nodes / pathology
Male
Sequence Deletion

Substances

Biomarkers, Tumor
ATM protein, human
Ataxia Telangiectasia Mutated Proteins