Multifunctional polypyrrole@Fe(3)O(4) nanoparticles for dual-modal imaging and in vivo photothermal cancer therapy

Small. 2014 Mar 26;10(6):1063-8. doi: 10.1002/smll.201302042. Epub 2013 Nov 27.

Abstract

Magnetic Fe3 O4 crystals are produced in situ on preformed polypyrrole (PPY) nanoparticles by rationally converting the residual Fe species in the synthetic system. The obtained PPY@Fe(3)O(4)composite nanoparticles exhibit good photostability and biocompatibility, and they can be used as multifunctional probes for MRI, thermal imaging, and photothermal ablation of cancer cells.

Keywords: MRI contrast agent; multifunctional photothermal agent; photothermal conversion; polypyrrole nanoparticles; thermal therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ferric Compounds / chemistry*
  • HeLa Cells
  • Humans
  • Hyperthermia, Induced / methods*
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Nude
  • Multimodal Imaging*
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Neoplasms / therapy*
  • Phototherapy / methods*
  • Polymers / chemistry*
  • Pyrroles / chemistry*
  • Spectrophotometry, Ultraviolet
  • Temperature

Substances

  • Ferric Compounds
  • Polymers
  • Pyrroles
  • ferric oxide
  • polypyrrole