Abstract
A previously undescribed and robust miR210 overexpression is shown in intestinal samples obtained from patients with radiation enteropathy and fibrotic cultured cells. In addition, miR-210 overexpression is repressed by antifibrotic treatment combining pentoxifylline and α-tocopherol.
Keywords:
Anti-fibrotic treatment; Pentoxifylline; Radiation enteropathy; Radiation-induced fibrosis; Trolox; microRNA miR-210.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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Antioxidants / therapeutic use
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Cells, Cultured / drug effects
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Cells, Cultured / metabolism
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Drug Therapy, Combination
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Fibrosis / drug therapy
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Fibrosis / metabolism
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Humans
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Hypoxia / metabolism
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Intestinal Diseases / drug therapy*
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Intestinal Diseases / metabolism
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MicroRNAs / antagonists & inhibitors
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MicroRNAs / metabolism*
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Molecular Targeted Therapy / methods
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Myocytes, Smooth Muscle / drug effects
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Myocytes, Smooth Muscle / metabolism
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Pentoxifylline / therapeutic use*
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Platelet Aggregation Inhibitors / therapeutic use*
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RNA / metabolism
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RNA, Mitochondrial
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Radiation Injuries / drug therapy*
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Radiation Injuries / metabolism
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Radiation-Protective Agents / therapeutic use*
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Radiotherapy / adverse effects
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alpha-Tocopherol / therapeutic use
Substances
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Antioxidants
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MIRN210 microRNA, human
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MicroRNAs
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Platelet Aggregation Inhibitors
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RNA, Mitochondrial
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Radiation-Protective Agents
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RNA
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alpha-Tocopherol
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Pentoxifylline