Comparison of several functional methods to evaluate the immune response on stable kidney transplant patients

J Immunol Methods. 2014 Jan 31;403(1-2):62-5. doi: 10.1016/j.jim.2013.11.019. Epub 2013 Nov 27.

Abstract

The introduction of new immunosuppressive drugs in the last two decades has been associated with a significant decline in the prevalence of acute rejection and a huge improvement of graft survival. Monitoring blood levels of immunosuppressive drugs is the most common way to control drug doses in renal transplant patients. This approach is useful and widely used but doesn't give accurate information about the immune status of the patient. For this goal, there are many "in house" protocols which give more information, but cannot be standardized, limiting their applicability to compare results between different laboratories. In this study we compare three classical functional methods to evaluate the immune response: Mixed lymphocyte reaction (MLR), phytohemagglutinin stimulated peripheral blood lymphocytes (PBLs), and anti-CD3 monoclonal antibodies (mAbs) against PBL with the only FDA-labeled assay to measure the patient immune status: Cylex ImmuKnow® that measures the intracelullar ATP in CD4+ lymphocytes. We used n=111 stable renal transplant patients, all the patients with more than one year functioning grafts. We referred the results to a control population of healthy blood donors (n=125).

Results: Measurement of intracellular ATP in CD4+ lymphocytes is able to differentiate immunosuppressed populations in renal transplant patients from health controls (242.30±21.62 vs. 386.43±25.12, p 0.0001). By contrary, there were no differences between controls and renal recipients when functional response was measured by MLR, PHA and anti-CD3 mAbs (2.48±0.45 vs. 2.37±0.41; 2.84±0.76 vs. 2.37±0.32; 2.32±0.34 vs. 1.89±0.38 respectively). In summary, our results show that the measurement of ATP in CD4+ lymphocytes gives more accurate information in comparison to the classical methods.

Keywords: ATP levels; ImmuKnow; Immunosuppression; Lymphocyte proliferation; Mixed lymphocyte reaction; WST-1.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Biomarkers / metabolism
  • CD3 Complex / immunology
  • CD3 Complex / metabolism
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / metabolism
  • Cells, Cultured
  • Drug Monitoring* / methods
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / blood
  • Immunosuppressive Agents / therapeutic use*
  • Kidney Transplantation* / adverse effects
  • Lymphocyte Activation / drug effects
  • Lymphocyte Culture Test, Mixed
  • Male
  • Middle Aged
  • Mitogens
  • Monitoring, Immunologic* / methods
  • Phytohemagglutinins
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal
  • Biomarkers
  • CD3 Complex
  • Immunosuppressive Agents
  • Mitogens
  • Phytohemagglutinins
  • Adenosine Triphosphate