Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents

Dongli Lu; Yongqiang Liu; Haji Akber Aisa

doi:10.1016/j.fitote.2013.11.008

Jatrophane diterpenoid esters from Euphorbia sororia serving as multidrug resistance reversal agents

Fitoterapia. 2014 Jan:92:244-51. doi: 10.1016/j.fitote.2013.11.008. Epub 2013 Nov 27.

Authors

Dongli Lu¹, Yongqiang Liu², Haji Akber Aisa³

Affiliations

¹ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Urumqi 830011, China; University of the Chinese Academy of Sciences, Beijing 100039, China.
² The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Urumqi 830011, China.
³ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Urumqi 830011, China. Electronic address: [email protected].

PMID: 24291755
DOI: 10.1016/j.fitote.2013.11.008

Abstract

Six (1-6) new jatrophane diterpenoid esters together with four known compounds (7-10) were isolated from the acetone extract of fructus Euphorbia sororia. Their structures were elucidated by the spectral technology, including the 2D NMR experiments (HMQC, HMBC and NOESY). The absolute configuration of compound 1 and compound 7 were first confirmed by X-ray crystallographic analysis. Compounds 1-7 were assayed for their antiproliferative activity in human cancer cell lines: human mammary adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549). All the compounds were inactive for the cell lines. The multidrug-resistance reversal activity was also tested on KBv200 cells and compound 2 displayed strong multidrug resistance reversal activity, outperforming verapamil at 10 μM.

Keywords: Euphorbia sororia; Jatrophane diterpenoid esters; Multidrug resistance reversal activity; Uyghur medicine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / drug therapy*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use
Breast Neoplasms / drug therapy
Cell Line, Tumor
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology
Diterpenes / therapeutic use*
Drug Resistance, Multiple / drug effects*
Drug Resistance, Neoplasm / drug effects*
Esters
Euphorbia / chemistry*
Female
Fruit
Humans
Lung Neoplasms / drug therapy
MCF-7 Cells
Molecular Structure
Phytotherapy*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*

Substances

Antineoplastic Agents, Phytogenic
Diterpenes
Esters
Plant Extracts
jatrophane