Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete

Nicola Detta; Giulia Frisso; Giuseppe Limongelli; Michele Marzullo; Raffaele Calabrò; Francesco Salvatore

doi:10.1016/j.ijcard.2013.11.013

Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete

Int J Cardiol. 2014 Jan 1;170(3):e63-5. doi: 10.1016/j.ijcard.2013.11.013. Epub 2013 Nov 12.

Authors

Nicola Detta¹, Giulia Frisso², Giuseppe Limongelli³, Michele Marzullo⁴, Raffaele Calabrò³, Francesco Salvatore⁵

Affiliations

¹ CEINGE-Biotecnologie Avanzate s.c.ar.l., Naples, Italy.
² CEINGE-Biotecnologie Avanzate s.c.ar.l., Naples, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy.
³ Unità Operativa Clinica di Cardiologia, Ospedale dei Colli, Seconda Università di Napoli, Naples, Italy.
⁴ Medicina dello Sport, Dipartimento di Scienze Biomediche Avanzate, University of Naples Federico II, Naples, Italy.
⁵ CEINGE-Biotecnologie Avanzate s.c.ar.l., Naples, Italy; IRCCS-Fondazione SDN, Naples, Italy. Electronic address: [email protected].

PMID: 24295898
DOI: 10.1016/j.ijcard.2013.11.013

No abstract available

Keywords: Athletes' sudden death risk; Electrophysiological cell measurements; Genetic analysis of SSS; Mutation functional analysis; Sick sinus syndrome; Sudden death prevention.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Athletes*
Bradycardia / epidemiology
Bradycardia / genetics
Child
Death, Sudden, Cardiac / epidemiology*
Family Health
Female
Humans
Male
Middle Aged
NAV1.5 Voltage-Gated Sodium Channel / genetics*
Pedigree
Risk Factors
Sick Sinus Syndrome / epidemiology*
Sick Sinus Syndrome / genetics*

Substances

NAV1.5 Voltage-Gated Sodium Channel
SCN5A protein, human