Abstract
RET (rearranged during transfection) is a receptor tyrosine kinase involved in the development of neural crest derived cell lineages, kidney, and male germ cells. Different human cancers, including papillary and medullary thyroid carcinomas, lung adenocarcinomas, and myeloproliferative disorders display gain-of-function mutations in RET. Accordingly, RET protein has become a promising molecular target for cancer treatment.
MeSH terms
-
Carcinoma / drug therapy
-
Carcinoma / enzymology*
-
Carcinoma / genetics
-
Carcinoma, Neuroendocrine
-
Carcinoma, Papillary
-
Humans
-
Mutation
-
Protein Kinase Inhibitors / therapeutic use
-
Proto-Oncogene Proteins c-ret / antagonists & inhibitors
-
Proto-Oncogene Proteins c-ret / genetics
-
Proto-Oncogene Proteins c-ret / metabolism*
-
Thyroid Cancer, Papillary
-
Thyroid Neoplasms / drug therapy
-
Thyroid Neoplasms / enzymology*
-
Thyroid Neoplasms / genetics
Substances
-
Protein Kinase Inhibitors
-
Proto-Oncogene Proteins c-ret
-
RET protein, human
Supplementary concepts
-
Thyroid cancer, medullary