Abstract
A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enantioselectivity with a new tailored C1-symmetric biaryl-saturated imidazolium-derived NHC catalyst.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acylation
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Alcohols / chemistry
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Alkenes / chemistry*
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Catalysis
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Computer Simulation*
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Heterocyclic Compounds / chemistry*
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Hydroxylation
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Methane / analogs & derivatives*
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Methane / chemistry
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Models, Chemical*
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Organophosphonates / chemistry*
Substances
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Alcohols
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Alkenes
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Heterocyclic Compounds
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Organophosphonates
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carbene
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Methane