[Relationship between biochemical parameters of cerebrospinal fluid and the course of multiple sclerosis]

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10 Pt 2):43-6.
[Article in Russian]

Abstract

We examined 60 patients with remitting multiple sclerosis (disability 3,5±1.6 EDSS scores). The relative risk of rapid progression of neurologic impairment was associated with the higher levels of matrix metalloproteinase-2, soluble platelet endothelial cell adhesion molecule-1 (sPECAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the cerebrospinal fluid. The relative risk of exacerbation of the disease in the next three years was associated with the level of tumor necrosis factor alpha and matrix metalloproteinase-2.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / cerebrospinal fluid
  • Disease Progression
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / diagnosis
  • Platelet Endothelial Cell Adhesion Molecule-1 / cerebrospinal fluid*
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / cerebrospinal fluid*
  • Vascular Cell Adhesion Molecule-1 / cerebrospinal fluid*

Substances

  • Biomarkers
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Tumor Necrosis Factor-alpha
  • Vascular Cell Adhesion Molecule-1