Abstract
Professor W. Wallace Cleland, the architect of modern steady-state enzyme kinetics, died on March 6, 2013, from injuries sustained in a fall outside of his home. He will be most remembered for giving the enzyme community Ping-Pong kinetics and the invention of dithiothreitol (DTT). He pioneered the utilization of heavy atom isotope effects for the elucidation of the chemical mechanisms of enzyme-catalyzed reactions. His favorite research journal was Biochemistry, in which he published more than 135 papers beginning in 1964 with the disclosure of DTT.
Publication types
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Biography
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Historical Article
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Portrait
MeSH terms
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Biocatalysis* / drug effects
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Biochemistry / history*
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Deuterium Exchange Measurement / history
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Dithiothreitol / chemistry
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Dithiothreitol / pharmacology
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Enzyme Inhibitors / pharmacology
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Enzymes / chemistry
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Enzymes / metabolism*
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History, 20th Century
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History, 21st Century
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Kinetics*
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Malate Dehydrogenase (NADP+) / antagonists & inhibitors
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Malate Dehydrogenase (NADP+) / chemistry
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Malate Dehydrogenase (NADP+) / metabolism
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Models, Biological*
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Oxidation-Reduction / drug effects
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Philately / history
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Proteins / chemistry
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Proteins / metabolism
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Reducing Agents / chemistry
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Reducing Agents / pharmacology
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Spectrophotometry / history
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Sulfhydryl Reagents / chemistry
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Sulfhydryl Reagents / pharmacology
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United States
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Wisconsin
Substances
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Enzyme Inhibitors
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Enzymes
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Proteins
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Reducing Agents
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Sulfhydryl Reagents
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Malate Dehydrogenase (NADP+)
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Dithiothreitol