Chemotherapy-induced acral erythema with involvement of the face and neck: A case report

Toxicol Ind Health. 2016 May;32(5):791-4. doi: 10.1177/0748233713511514. Epub 2013 Dec 5.

Abstract

Chemotherapy-induced acral erythema (CIAE) is a cutaneous response to diverse chemotherapeutic drug administration. These drugs cause symmetrical and painful erythema of palmoplantar surfaces. Bulla formation, desquamation, and subsequent reepithelialization may occur. Commonly, the lesions slowly resolve over 7-15 days, through desquamation, followed by regeneration of the skin. Here, we described a case of CIAE, with involvement of face and neck in a patient treated for breast cancer using a number of chemotherapeutic agents. Face involvement in CIAE has not been previously reported in the literature.

Keywords: Acral erythema; chemotherapy; face and neck.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Breast Neoplasms / drug therapy
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / therapeutic use
  • Docetaxel
  • Dose-Response Relationship, Drug
  • Epirubicin / adverse effects
  • Epirubicin / therapeutic use
  • Face / pathology*
  • Female
  • Hand-Foot Syndrome / diagnosis*
  • Hand-Foot Syndrome / drug therapy
  • Humans
  • Neck / pathology*
  • Pyridoxine / pharmacology
  • Skin / drug effects
  • Skin / pathology
  • Taxoids / adverse effects
  • Taxoids / therapeutic use
  • Trastuzumab / adverse effects
  • Trastuzumab / therapeutic use
  • Vitamin B Complex / pharmacology
  • Young Adult

Substances

  • Antineoplastic Agents
  • Taxoids
  • Vitamin B Complex
  • Docetaxel
  • Epirubicin
  • Cyclophosphamide
  • Pyridoxine
  • Trastuzumab