A stimuli-responsive nanogel-based sensitive and selective fluorescent sensor for Cr(3+) with thermo-induced tunable detection sensitivity

Macromol Rapid Commun. 2014 Feb;35(3):323-9. doi: 10.1002/marc.201300810. Epub 2013 Dec 9.

Abstract

Stimuli-responsive poly(N-isopropylacrylamide) nanogel with covalently labeled rhodamine B urea derivatives (P(NIPAM-co-RhBUA)) is utilized as a sensitive fluorescent probe for Cr(3+) in aqueous solution, and its thermo-induced tunable detection capacity is investigated. At 20 °C, non-fluorescent nanogel can selectively bind with Cr(3+) over some other metal ions, leading to prominent fluorescence OFF-ON switching due to the recognition of RhBUA with Cr(3+) . Upon heating above the phase transition temperature, enhanced fluorescence intensity is observed (≈61-fold increase at 45 °C) for the nanogel in the presence of Cr(3+) , accompanied with an improved detection sensitivity, which suggest that hydrophobic microenvironment generated in the collapsed nanogel plays an active role for their detection performance.

Keywords: Cr3+ sensors; emulsion polymerization; fluorescence; nanogel; stimuli-sensitive polymers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Chromium / analysis*
  • Fluorescent Dyes / chemistry*
  • Molecular Structure
  • Nanogels
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry*
  • Polyethyleneimine / chemical synthesis
  • Polyethyleneimine / chemistry*
  • Rhodamines / chemistry
  • Sensitivity and Specificity
  • Temperature

Substances

  • Acrylic Resins
  • Fluorescent Dyes
  • Nanogels
  • Rhodamines
  • polyethylene glycol polyethyleneimine nanogel
  • Chromium
  • poly-N-isopropylacrylamide
  • Polyethylene Glycols
  • Polyethyleneimine
  • rhodamine B