High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging

Chem Commun (Camb). 2014 Feb 7;50(10):1192-4. doi: 10.1039/c3cc47616b.

Abstract

[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

MeSH terms

  • Benzamides / chemical synthesis*
  • Benzamides / chemistry
  • Fluorine Radioisotopes*
  • Microfluidics*
  • Positron-Emission Tomography*

Substances

  • Benzamides
  • Fluorine Radioisotopes
  • fallypride