Abstract
Two new rubrolides, rubrolides R (1) and S (2), were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus OUCMDZ-1925. Their structures were elucidated on the basis of spectroscopic analysis and X-ray single crystal diffraction. Compound 1 showed comparable or superior antioxidation against 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals to those of trolox and ascorbic acid with an IC₅₀ value of 1.33 mM. Compound 2 showed comparable or superior anti-influenza A (H1N1) virus activity to that of ribavirin with an IC₅₀ value of 87.1 μM. Both compounds 1 and 2 showed weak cytotoxicity against the K562 cell line with IC₅₀ values of 12.8 and 10.9 μM, respectively.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / metabolism
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Antiviral Agents / pharmacology
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Aspergillus / growth & development
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Aspergillus / metabolism*
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Cell Survival / drug effects
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China
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Crystallography, X-Ray
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Drug Discovery*
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Estuaries
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Fermentation
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Fishes / microbiology
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Furans / chemistry
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Furans / isolation & purification*
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Furans / metabolism
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Furans / pharmacology
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects*
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Influenza A Virus, H1N1 Subtype / growth & development
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Inhibitory Concentration 50
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K562 Cells
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
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Magnetic Resonance Spectroscopy
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Molecular Structure
Substances
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Antineoplastic Agents
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Antioxidants
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Antiviral Agents
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Furans
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rubrolide R
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rubrolide S