Wnt and Bmp fit germ cells to a T

Andrea V Cantú; Diana J Laird

doi:10.1016/j.devcel.2013.11.020

Wnt and Bmp fit germ cells to a T

Dev Cell. 2013 Dec 9;27(5):485-7. doi: 10.1016/j.devcel.2013.11.020.

Authors

Andrea V Cantú¹, Diana J Laird²

Affiliations

¹ Department of Ob/Gyn and Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.
² Department of Ob/Gyn and Reproductive Sciences, Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA. Electronic address: [email protected].

Abstract

Reporting in Developmental Cell, Aramaki et al. (2013) identify T as a key mediator of primordial germ cell (PGC) specification in the embryo. Deconstruction of how Bmp and Wnt signals regulate the expression and targeting of T to regulatory elements of either mesodermal or PGC genes has implications for differentiation in vitro.

Publication types

Comment

MeSH terms

Animals
Brachyury Protein
Embryonic Stem Cells / cytology*
Embryonic Stem Cells / metabolism*
Female
Fetal Proteins / metabolism*
Germ Cells / cytology*
Germ Cells / metabolism*
Male
Pregnancy
T-Box Domain Proteins / metabolism*

Substances

Fetal Proteins
T-Box Domain Proteins
Brachyury Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding