Making sense of HIV innate sensing

Andrea L Cox; Robert F Siliciano

doi:10.1016/j.immuni.2013.11.014

Making sense of HIV innate sensing

Immunity. 2013 Dec 12;39(6):998-1000. doi: 10.1016/j.immuni.2013.11.014.

Authors

Andrea L Cox¹, Robert F Siliciano²

Affiliations

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: [email protected].
² Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Baltimore, MD 21201, USA.

Abstract

Innate sensing of HIV is important in host control and pathogenesis. In this issue of Immunity, Lahaye et al. (2013) demonstrate that HIV capsid-cyclophilin A interactions affect viral cDNA sensing by the DNA sensor cCAS and contribute to differential pathogenesis of HIV-1 and HIV-2.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Capsid / immunology*
DNA, Complementary / metabolism*
Dendritic Cells*
HIV Infections / immunology*
HIV-1 / immunology*
HIV-2 / immunology*
Humans
Nucleotidyltransferases / metabolism*

Substances

DNA, Complementary
Nucleotidyltransferases
cGAS protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding