New twist on an ancient innate immune pathway

Stephane Lajoie; Marsha Wills-Karp

doi:10.1016/j.immuni.2013.11.015

New twist on an ancient innate immune pathway

Immunity. 2013 Dec 12;39(6):1000-2. doi: 10.1016/j.immuni.2013.11.015.

Authors

Stephane Lajoie¹, Marsha Wills-Karp²

Affiliations

¹ Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
² Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address: [email protected].

Abstract

Activation of the complement system has long been known to be regulated by a series of steps involving fluid-phase convertases. In this issue of Immunity, Liszewski et al. (2013) report the discovery of an intracellular cathepsin-L-dependent C3 activation pathway.

Publication types

Comment

MeSH terms

B-Lymphocyte Subsets / cytology*
CD4-Positive T-Lymphocytes / immunology*
Cathepsin L / metabolism*
Cell Differentiation*
Complement Activation / physiology*
Complement C3 / metabolism*
Homeostasis / physiology*
Humans

Substances

Complement C3
CTSL protein, human
Cathepsin L

Abstract

Publication types

MeSH terms

Substances

Grants and funding