First case of 18F-FACBC PET/CT-guided salvage retroperitoneal lymph node dissection for disease relapse after radical prostatectomy for prostate cancer and negative 11C-choline PET/CT: new imaging techniques may expand pioneering approaches

Urol Int. 2014;92(2):242-5. doi: 10.1159/000354730. Epub 2013 Dec 7.

Abstract

We present the first case of salvage retroperitoneal lymph node dissection based on the results of (18)F-FACBC PET/CT performed for a prostate-specific antigen relapse after radical prostatectomy. The patients underwent (11)C-choline PET/CT, which turned out negative, while (18)F-FACBC PET/CT visualized two lymph node metastases confirmed at pathological examination. Preliminary clinical reports showed an improvement in the detection rate of 20-40% for (18)F-FACBC in comparison with (11)C-choline, rendering the (18)F-FACBC the potential radiotracer of the future. Salvage surgery for prostate cancer is a fascinating but controversial approach. New diagnostic tools may improve its potential by increasing the assessment and the selection of the patients.

Publication types

  • Case Reports

MeSH terms

  • Carbon Radioisotopes / chemistry
  • Carboxylic Acids / chemistry*
  • Choline / chemistry
  • Cyclobutanes / chemistry*
  • Humans
  • Lymph Node Excision / methods*
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / surgery
  • Positron-Emission Tomography / methods
  • Prostate-Specific Antigen / metabolism
  • Prostatectomy
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / surgery*
  • Salvage Therapy / methods*
  • Tomography, X-Ray Computed / methods
  • Treatment Outcome

Substances

  • Carbon Radioisotopes
  • Carboxylic Acids
  • Cyclobutanes
  • fluciclovine F-18
  • Prostate-Specific Antigen
  • Choline