forqs: forward-in-time simulation of recombination, quantitative traits and selection

Bioinformatics. 2014 Feb 15;30(4):576-7. doi: 10.1093/bioinformatics/btt712. Epub 2013 Dec 10.

Abstract

Summary: forqs is a forward-in-time simulation of recombination, quantitative traits and selection. It was designed to investigate haplotype patterns resulting from scenarios where substantial evolutionary change has taken place in a small number of generations due to recombination and/or selection on polygenic quantitative traits.

Availability and implementation: forqs is implemented as a command-line C++ program. Source code and binary executables for Linux, OSX and Windows are freely available under a permissive BSD license: https://bitbucket.org/dkessner/forqs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Computer Simulation
  • Evolution, Molecular
  • Genetics, Population
  • Haplotypes / genetics
  • Humans
  • Quantitative Trait Loci / genetics*
  • Recombination, Genetic / genetics*
  • Selection, Genetic / genetics*
  • Software*