Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade

Chem Commun (Camb). 2014 Feb 7;50(10):1231-3. doi: 10.1039/c3cc47921h.

Abstract

An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Epoxy Compounds / chemistry*
  • Indoles / chemistry*
  • Ligands
  • Molecular Structure
  • Stereoisomerism
  • Vanadium / chemistry*

Substances

  • Epoxy Compounds
  • Indoles
  • Ligands
  • Vanadium
  • tryptophol