Abstract
The complete genomes of two swine influenza viruses from England were sequenced. Phylogenetic analysis revealed classical swine H1N1 viruses, one of which, A/swine/London, is closely related to virus strains of the early 1930s. Both strains are also antigenically related to A/swine/Iowa/15/1930, the strain originally isolated by Richard Shope. The source of A/swine/London is unknown, but its relationship to early classical swine influenza viruses suggests that the emergence of these viruses in Europe has to be antedated by 15-20 years.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Viral / genetics
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England
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Evolution, Molecular
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History, 20th Century
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Humans
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Influenza A Virus, H1N1 Subtype / classification*
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Influenza A Virus, H1N1 Subtype / genetics
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Influenza A Virus, H1N1 Subtype / isolation & purification
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Influenza, Human / epidemiology*
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Influenza, Human / history
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Influenza, Human / virology*
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Orthomyxoviridae Infections / epidemiology*
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Orthomyxoviridae Infections / history
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Orthomyxoviridae Infections / virology*
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Swine
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Swine Diseases / epidemiology*
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Swine Diseases / history
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Swine Diseases / virology*