Abstract
The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry*
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Kentucky
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthoquinones / chemistry
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / chemistry*
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Streptomyces / chemistry*
Substances
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Antifungal Agents
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Naphthoquinones
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Polyketides
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ruthmycin
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frenolicin B