Resistin gene variations are associated with the metabolic syndrome in Japanese men

Yoshihiro Miyamoto; Hiroko Morisaki; Yoshihiro Kokubo; Itaru Yamanaka; Hitonobu Tomoike; Akira Okayama; Yasunao Yoshimasa; Takayuki Morisaki

doi:10.1016/j.orcp.2008.11.003

Resistin gene variations are associated with the metabolic syndrome in Japanese men

Obes Res Clin Pract. 2009 May;3(2):I-II. doi: 10.1016/j.orcp.2008.11.003.

Authors

Yoshihiro Miyamoto¹, Hiroko Morisaki², Yoshihiro Kokubo², Itaru Yamanaka², Hitonobu Tomoike², Akira Okayama², Yasunao Yoshimasa², Takayuki Morisaki²

Affiliations

¹ Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan. Electronic address:[email protected].
² Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.

PMID: 24345560
DOI: 10.1016/j.orcp.2008.11.003

Abstract

Objectives: Metabolic syndrome is defined as a cluster of risk factors for cardiovascular disease and is intimately related to insulin resistance. Resistin, a hormone secreted by adipocytes, may play an important role in communication between adiposity and insulin resistance. We investigated whether variations in the resistin gene associated with metabolic syndrome in a Japanese population.

Method: We analyzed five SNPs, two of which were located in the promoter region (-420C > G, -358G > A), two in intron 2 (+157C > T, +299G > A), and one in the 3'-untranslated region (3'UTR) (+1263G > C) across the resistin gene in 2968 residents from an urban Japanese cohort. The associations of SNPs and haplotypes with metabolic syndrome were analyzed.

Results: The GAC and CGC haplotypes (comprising -420C > G, -358G > A, and +157C > T) had opposite influences on metabolic syndrome susceptibility in men; the former was associated with an increased risk and the latter with a decreased risk. We also found that the -420G allele was significantly associated with an increased risk of metabolic syndrome and significantly correlated with high diastolic blood pressure, high HOMA-IR values, high serum triglyceride levels, low HDL-cholesterol levels and high serum levels of adiponectin.

Conclusion: We identified a risk-conferring SNP and haplotype of the resistin gene for metabolic syndrome in a Japanese population. Our data suggested that resistin gene is a susceptibility gene for metabolic syndrome in Japanese men.