Association between the STK15 F31I polymorphism and cancer susceptibility: a meta-analysis involving 43,626 subjects

PLoS One. 2013 Dec 13;8(12):e82790. doi: 10.1371/journal.pone.0082790. eCollection 2013.

Abstract

The association between the Serine/threonine kinase 15 (STK15) F31I polymorphism (rs2273535) and cancer susceptibility remains controversial. To further investigate this potential relationship, we conducted a comprehensive meta-analysis of 27 published studies involving a total of 19,267 multiple cancer cases and 24,359 controls. Our results indicate statistical evidence of an association between the STK15 F31I polymorphism and the increased risk of overall cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T. In a stratified analysis by cancer type, there was an increased risk of breast cancer in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA, and A vs. T, as well as esophageal cancer in two genetic models: AA vs. TA+TT and AA vs. TA. In a stratified analysis by ethnicity, there was a significant increase in cancer risk among Asians, but not Caucasians, in four genetic models: AA vs. TA+TT, AA vs. TT, AA vs. TA and A vs. T. In addition, a stratified analysis by ethnicity in the breast cancer subgroup revealed a significant increase in cancer risk among Asians in two genetic models: AA vs. TA+TT and AA vs. TT, as well as among Caucasians in one genetic model: AA vs. TA. In summary, this meta-analysis demonstrates that the STK15 F31I polymorphism may be a risk factor for cancer.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Aurora Kinase A / genetics*
  • Codon
  • Genetic Predisposition to Disease*
  • Humans
  • Neoplasms / diagnosis
  • Neoplasms / genetics*
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Publication Bias

Substances

  • Codon
  • Aurora Kinase A

Grants and funding

This study was supported by Jiangsu University Clinical medicine science and technology development fund (JLY20120004). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.