Keloid is a kind of pathological scar of skin, which would seriously impair patient's quality of life. But until today, no reliable theory to explain the development of keloid has been established. Recent studies have found that toll-like receptors plays an important role in the formation of keloid. This article reviews the advances in the research of toll-like receptors making contribution to the pathogenesis of keloid. Further researches could lead to a new strategy in treating keloid.