Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation

Arch Toxicol. 2014 Jan;88(1):179-80. doi: 10.1007/s00204-013-1173-7. Epub 2013 Dec 19.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Glucuronosyltransferase / metabolism*
  • Humans
  • Hypnotics and Sedatives / pharmacokinetics
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / therapeutic use*
  • Leukemia, Myeloid, Acute / drug therapy
  • Lorazepam / pharmacokinetics
  • Lorazepam / pharmacology
  • Lorazepam / therapeutic use*

Substances

  • Hypnotics and Sedatives
  • UGT2B7 protein, human
  • Glucuronosyltransferase
  • UGT2B4 protein, human
  • Lorazepam