A new view of integrin αIIbβ3 bound to membrane

Blood. 2013 Dec 19;122(26):4157-9. doi: 10.1182/blood-2013-10-534149.

Abstract

In this issue of Blood, Choi et al report a 3-dimensional (3D) reconstruction model of integrin aIIbb3 in its latent state which challenges the existing paradigm and provides new insights into the mechanism of integrin activation.

Publication types

  • Comment

MeSH terms

  • Humans
  • Imaging, Three-Dimensional*
  • Models, Chemical*
  • Platelet Glycoprotein GPIIb-IIIa Complex / chemistry*
  • Platelet Glycoprotein GPIIb-IIIa Complex / metabolism*

Substances

  • Platelet Glycoprotein GPIIb-IIIa Complex