Abstract
Six chromene stilbenoids and one chromane stilbenoid were isolated from the African tree Hymenocardia acida. Several were moderately active against methicillin-resistant Staphylococcus aureus clinical isolate MRSA-108, including hymenocardichromanic acid, which was active at 8 μg/ml. None had IC50 values <20 μM in antiproliferation assays against several human cancer cell lines.
Keywords:
Chromane; Chromene; Hymenocardia acida; Methicillin-resistant Staphylococcus aureus (MRSA); Phyllanthaceae.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Phyllanthus / chemistry*
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Plant Leaves / chemistry
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Stilbenes / chemistry
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Stilbenes / isolation & purification
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Stilbenes / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Benzopyrans
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Stilbenes