A click chemistry approach to secosteroidal macrocycles

Malika Ibrahim-Ouali; Khalil Hamze

doi:10.1016/j.steroids.2013.12.002

A click chemistry approach to secosteroidal macrocycles

Steroids. 2014 Feb:80:102-10. doi: 10.1016/j.steroids.2013.12.002. Epub 2013 Dec 18.

Authors

Malika Ibrahim-Ouali¹, Khalil Hamze²

Affiliations

¹ Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397 Marseille, France. Electronic address: [email protected].
² Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397 Marseille, France.

PMID: 24361500
DOI: 10.1016/j.steroids.2013.12.002

Abstract

A new synthetic pathway towards secosteroidal macrocycles was described via a reaction of cycloaddition as the key step. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported.

Keywords: 1,2,3-Triazole; Cholic acid; Macrocycles; ‘Click chemistry’.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Click Chemistry*
Cyclization
Macrocyclic Compounds / chemical synthesis*
Macrocyclic Compounds / chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Secosteroids / chemical synthesis*
Secosteroids / chemistry

Substances

Macrocyclic Compounds
Secosteroids