A new protocol to detect multiple foodborne pathogens with PCR dipstick DNA chromatography after a six-hour enrichment culture in a broad-range food pathogen enrichment broth

Biomed Res Int. 2013:2013:295050. doi: 10.1155/2013/295050. Epub 2013 Dec 2.

Abstract

A quick foodborne pathogen screening method after six-hour enrichment culture with a broad-range food pathogen enrichment broth is described. Pathogenic factors of Salmonella enterica, Shigella spp., enteroinvasive Escherichia coli, and enterohemorrhagic E. coli are amplified with a cocktail primer and rapid polymerase chain reaction (PCR), which finishes amplification in 30 min. The PCR amplicon was differentiated with a dipstick DNA chromatography assay in 5-10 min. Starting from a four- to six-hour enrichment culture, this assay was finished within 45 min. Detection sensitivity of this protocol was less than 2.5 CFU/25 g for S. enterica and 3.3 CFU/25 g for enterohemorrhagic E. coli in spiked ground meat experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colony Count, Microbial
  • DNA, Bacterial / genetics
  • DNA, Bacterial / isolation & purification*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli / pathogenicity
  • Food Microbiology*
  • Foodborne Diseases / genetics*
  • Foodborne Diseases / microbiology
  • Humans
  • Polymerase Chain Reaction
  • Salmonella enterica / genetics
  • Salmonella enterica / isolation & purification
  • Salmonella enterica / pathogenicity
  • Shigella / genetics
  • Shigella / isolation & purification
  • Shigella / pathogenicity

Substances

  • DNA, Bacterial