From molecular understanding to clinical advances

Nat Rev Urol. 2014 Feb;11(2):77-9. doi: 10.1038/nrurol.2013.307. Epub 2013 Dec 24.

Abstract

Big data and computational biology brought to the forefront a number of potential actionable mutations and drug targets in clear cell renal cell carcinoma in 2013. As we continue to unravel the molecular underpinnings of tumorigenesis and progression, the clinical benefits will eventually be reaped.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma, Renal Cell / metabolism*
  • Carcinoma, Renal Cell / secondary*
  • Humans
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Kidney Neoplasms / metabolism*
  • Kidney Neoplasms / pathology*
  • Receptors, CXCR4 / metabolism*
  • Transcription Factors / metabolism*
  • Von Hippel-Lindau Tumor Suppressor Protein / metabolism*

Substances

  • Hypoxia-Inducible Factor 1
  • Receptors, CXCR4
  • Transcription Factors
  • Von Hippel-Lindau Tumor Suppressor Protein