Enhancing the resolution of multi-dimensional heteronuclear NMR spectra of intrinsically disordered proteins by homonuclear broadband decoupling

Chem Commun (Camb). 2014 Feb 11;50(12):1488-90. doi: 10.1039/c3cc48135b.

Abstract

Limited spectral resolution in the proton dimension of NMR spectra is a severe problem in intrinsically disordered proteins. Here we show that homonuclear broadband proton decoupling of the direct and indirect dimensions of multi-dimensional NMR spectra significantly enhances their resolution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Intrinsically Disordered Proteins / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular / methods*

Substances

  • Intrinsically Disordered Proteins