Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach

Marco Candela; Elena Biagi; Patrizia Brigidi; Paul W O'Toole; Willem M De Vos

doi:10.1016/j.mad.2013.12.004

Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach

Mech Ageing Dev. 2014 Mar-Apr:136-137:70-5. doi: 10.1016/j.mad.2013.12.004. Epub 2013 Dec 25.

Authors

Marco Candela¹, Elena Biagi², Patrizia Brigidi², Paul W O'Toole³, Willem M De Vos⁴

Affiliations

¹ Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. Electronic address: [email protected].
² Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
³ Department of Microbiology & Alimentary Pharmabiotic Centre, University College Cork, Ireland.
⁴ Laboratory of Microbiology, Wageningen University, The Netherlands, and Departments of Veterinary Biosciences and Bacteriology & Immunology, Helsinki University, Finland.

PMID: 24373997
DOI: 10.1016/j.mad.2013.12.004

Abstract

Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging.

Keywords: Diet; Frailty; Healthy aging; Inflammation; Intestinal microbiota.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Aging*
Diet*
Europe
Genomics
Health
Homeostasis
Humans
Inflammation
Intestines / microbiology*
Longevity
Microbiota*
Models, Biological
Transgenes