Abstract
Dabigatran is a direct thrombin inhibitor indicated for stroke and systemic embolism prevention in patients with non-valvular atrial fibrillation. No reversal agent exists, but hemodialysis has been proposed as dabigatran removal method. We report a case of an 80-year-old man presenting hemorrhage with dabigatran overdose caused by obstructive acute renal failure. Before nephrostomy, several hemodialysis sessions were necessary to remove dabigatran probably because of its large volume of distribution.
Keywords:
Acute renal injury; Dabigatran; Hemodialysis; Hémodialyse; Hémorragie; Insuffisance rénale aiguë; Overdose; Surdosage.
Copyright © 2013 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Acute Kidney Injury / chemically induced*
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Acute Kidney Injury / therapy*
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Aged, 80 and over
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Alzheimer Disease / complications
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Antithrombins / adverse effects*
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Antithrombins / therapeutic use
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Atrial Fibrillation / complications
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Benzimidazoles / adverse effects*
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Benzimidazoles / therapeutic use
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Blood Coagulation Disorders / chemically induced
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Dabigatran
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Diabetes Mellitus, Type 2 / complications
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Drug Overdose / therapy*
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Hemorrhage / etiology
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Humans
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Hyperkalemia / etiology
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Male
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Neoplasms / surgery
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Phlebitis / therapy
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Renal Dialysis / methods*
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beta-Alanine / adverse effects
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beta-Alanine / analogs & derivatives*
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beta-Alanine / therapeutic use
Substances
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Antithrombins
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Benzimidazoles
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beta-Alanine
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Dabigatran