Abstract
A 2-aminothieno[3,4-d]pyrimidine G-mimic deoxyribonucleoside, (th)dG, was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that (th)dG enables the visual detection of Z-DNA successfully based on different π-stacking of B- and Z-DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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DNA, B-Form / analysis*
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DNA, Z-Form / analysis*
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Deoxyguanosine / analogs & derivatives*
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Fluorescent Dyes / chemistry*
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Oligonucleotides / chemistry*
Substances
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DNA, B-Form
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DNA, Z-Form
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Fluorescent Dyes
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Oligonucleotides
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Deoxyguanosine