Abstract
The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 μM, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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4-Quinolones / chemistry
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4-Quinolones / isolation & purification*
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4-Quinolones / pharmacology
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Dose-Response Relationship, Drug
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HIV Core Protein p24 / antagonists & inhibitors
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Malvaceae / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Papua New Guinea
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Plant Stems / chemistry
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Quinolines
Substances
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4-Quinolones
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Alkaloids
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Anti-HIV Agents
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HIV Core Protein p24
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Quinolines
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waltherione C
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waltherione-A