Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides

Chem Commun (Camb). 2014 Feb 18;50(14):1682-4. doi: 10.1039/c3cc47989g. Epub 2014 Jan 6.

Abstract

A palladium-catalyzed dual C-H activation to construct C-C/C-N bonds for one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones is successfully developed. This approach involves using a pyrazolone moiety as an internal directing group for C-H activation, and provides a flexible strategy to access this polycyclic skeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon / chemistry*
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Hydrogen / chemistry*
  • Iodine / chemistry*
  • Palladium / chemistry*
  • Pyrazolones / chemical synthesis*
  • Pyrazolones / chemistry*

Substances

  • Pyrazolones
  • pyrazolone
  • Palladium
  • Carbon
  • Hydrogen
  • Iodine