Background and objective: Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancer. The objective of this study is to evaluate the survival of patients older than 65 with SCLC and analyze the independent prognostic factors in this group of patients.
Methods: A retrospective study has enrolled 160 cases of lung cancer aged over 65. The prognostic factors were analyzed by Kaplan-Meier and Cox multivariate proportional hazards model.
Results: ① The median follow-up time was 12 (2-109) months. 1-, 3-, and 5-year survival rate was 47.1%, 13.0%, 9.6% respectively, and 74.4%, 25.0%, 19.7% for limited-stage (LD), and 36.8%, 8.7%, 5.8% for extensive-stage (ED). Median survival time (MST) of all the patients was 12 months, 24 months for LD and 11 months for ED, respectively. ② Multivariate analysis suggested that performance status (PS) pre-treatment, the change of PS after treatment, stage, liver metastases and thoracic radiotherapy were the independent prognostic factors in all patients. ③ For LD-SCLC patients, PS pre-treatment, thoracic radiotherapy were the independent prognostic factors. The model of thoracic radiotherapy (concurrent chemoradiation vs sequential chemoradiation, early concurrent chemoradiation vs late concurrent chemoradiation) and prophylactic cranial irradiation (PCI) did not show significant difference. ④ For ED-SCLC patients, sex, the change of PS after treatment, chemotherapy, liver metastases, thoracic radiotherapy, PCI were the independent prognostic factors.
Conclusions: The survival time is related to PS and thoracic radiotherapy in eldly patients. Besides, it is also related to sex, chemotherapy, liver metastases and PCI for ED-SCLC.
背景与目的 肺癌是目前恶性肿瘤死亡的首要原因，2/3的患者年龄超过65岁，小细胞肺癌约占全部肺癌15%-20%。本研究旨在分析65岁以上老年小细胞肺癌患者的生存状况及预后因素。方法 回顾性研究160例65岁以上老年小细胞肺癌患者临床资料，采用Kaplan-Meier法及Cox多因素回归分析预后因素。结果 ①中位随访12个月（2个月-109个月）。全组1年、3年、5年生存率分别为47.1%、13.0%、9.6%，局限期为74.4%、25.0%、19.7%，广泛期为36.8%、8.7%、5.8%。全组中位生存期（median survival time, MST）12个月，局限期24个月、广泛期11个月。全组的中位无进展生存期（progression-free survival, PFS）6个月，局限期10个月、广泛期 5个月。②全组分析提示治疗前体能状态（performance status, PS）评分、治疗后PS改变、分期、有无肝转移、胸部放疗是独立预后因素。③局限期中，治疗前PS评分、胸部放疗是独立预后因素。 胸部放疗方式（同步放化疗 vs 序贯放疗、早期同步放化疗 vs 晚期同步放化疗）及是否行预防性全脑放疗，MST均未见统计学差异。④广泛期中性别、治疗后PS改变、化疗方案、有无肝转移、胸部放疗、预防性全脑放疗是独立预后因素。结论 老年小细胞肺癌患者生存期与PS评分和胸部放疗相关，而广泛期患者还与性别、化疗方案、有无肝转移及是否行预防性全脑放疗相关。