Abstract
A new T-cell receptor gene lies just 5' to the J alpha C alpha coding regions. Its placement in this location suggests a novel mechanism for the regulation of expression of one T-cell receptor polypeptide to another during ontogeny. Rearrangement of this locus occurs very early in thymic differentiation and its RNA expression parallels that of the gamma-chain in thymic subpopulations, making this a possible candidate for the recently described delta-chain of the T-cell receptor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation
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DNA / genetics
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DNA, Recombinant
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Gene Expression Regulation
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Macromolecular Substances
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RNA / genetics
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Receptors, Antigen, T-Cell / genetics*
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T-Lymphocytes / cytology*
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Thymus Gland / cytology
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Thymus Gland / embryology
Substances
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DNA, Recombinant
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Macromolecular Substances
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Receptors, Antigen, T-Cell
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RNA
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DNA