Molecular modelling of HLA-B*35:132

Int J Immunogenet. 2014 Jun;41(3):195-7. doi: 10.1111/iji.12105. Epub 2014 Jan 9.

Abstract

Here we describe the molecular modelling of the new variant HLA-B*35:132. This allele shows one mismatch with B*35:01:01:01 in exon 3 at position 575 where a T is substituted by a C, which implies an amino acidic change from Leucine to Proline. This seems not to alter the molecular structure and not to compromise the HLA complex and T-cell receptor interaction.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Bone Marrow Transplantation
  • Cloning, Molecular
  • Exons*
  • HLA-B35 Antigen / genetics*
  • HLA-B35 Antigen / immunology
  • Histocompatibility Testing
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Point Mutation*
  • Structural Homology, Protein
  • Tissue Donors

Substances

  • HLA-B35 Antigen