Over-expression of the overexpressed in lung cancer-1 is associated with poor prognosis in colorectal cancer

Anticancer Res. 2014 Jan;34(1):367-72.

Abstract

Background/aim: The overexpressed in lung cancer-1 (OLC1) protein is overexpressed in a variety of human tumors. The purpose of the present study was to determine whether increased expression of OLC1 is associated with colorectal cancer.

Materials and methods: OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining (IHC). Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis.

Results: Immunohistochemical results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1. OLC1 expression was significantly correlated with UICC stage (p<0.001) and histological differentiation (p<0.001) in colorectal cancer patients. The 5-year overall survival (OS) rates in patients with strong-positive and weak OLC1 staining were 16.6% and 95.3%, respectively (p<0.0001).

Conclusion: OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.

Keywords: Overexpressed in lung cancer 1 (OLC1); colorectal cancer; immunohistochemistry; prognosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / mortality*
  • Adenocarcinoma / pathology
  • Biomarkers, Tumor / metabolism*
  • Case-Control Studies
  • Colon / metabolism
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / mortality*
  • Colorectal Neoplasms / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oncogene Proteins / metabolism*
  • Prognosis
  • Rectum / metabolism
  • Survival Rate

Substances

  • Biomarkers, Tumor
  • IST1 protein, human
  • Oncogene Proteins