Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes

J Org Chem. 2014 Feb 7;79(3):993-1000. doi: 10.1021/jo4024864.

Abstract

Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.

MeSH terms

  • Alkenes
  • Catalysis
  • Hydrogenation
  • Iridium / chemistry*
  • Ligands
  • Molecular Structure
  • Phosphorus Compounds / chemical synthesis*
  • Phosphorus Compounds / chemistry
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Stereoisomerism

Substances

  • Alkenes
  • Ligands
  • Phosphorus Compounds
  • Pyridines
  • Iridium