Quality of life and voice assessment in patients with early-stage glottic cancer

Head Neck. 2015 Mar;37(3):340-6. doi: 10.1002/hed.23603. Epub 2014 Apr 10.

Abstract

Background: The purpose of this study was to assess the quality of life (QOL) and voice handicap in a sample of disease-free patients who had been treated at our center with radiotherapy (RT) or surgery for early glottic cancer.

Methods: QOL and voice handicap were assessed using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires Quality of Life Questionnaire-Core 30-questions (QLQ-C30) and Quality of Life Questionnaire-Head and Neck 35-questions (QLQ-H&N35) and the Voice Handicap Index (VHI).

Results: Ninety-one patients completed the questionnaires. Fifty-nine patients (65%) were treated with RT and 32 (35%) with surgery. QOL scores for the sample recorded, moderate limitations in 6 areas, and more than moderate limitations (>30 of 100) in 2 areas. Significant differences were found in emotional functioning (88.5 vs 76.6) and social contact (4.6 vs 12.1) on the EORTC questionnaires and on the VHI (6.1 vs 12.8), which favored the RT group.

Conclusion: In this cross-sectional study, voice quality, emotional functioning, and social contact were better in the RT group.

Keywords: glottic cancer; quality of life; quality of voice; radiotherapy.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Biopsy, Needle
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / radiotherapy*
  • Carcinoma, Squamous Cell / surgery*
  • Chi-Square Distribution
  • Cross-Sectional Studies
  • Early Diagnosis
  • Female
  • Follow-Up Studies
  • Glottis / pathology*
  • Glottis / radiation effects
  • Glottis / surgery
  • Humans
  • Immunohistochemistry
  • Laryngeal Neoplasms / mortality
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / radiotherapy*
  • Laryngeal Neoplasms / surgery*
  • Laryngectomy / methods
  • Male
  • Middle Aged
  • Quality of Life*
  • Risk Assessment
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Treatment Outcome
  • Voice Quality