A 76-year-old woman was referred to our hospital with a non-healing ulcer and intractable rest pain. Diagnostic angiography revealed total occlusion of long iliac (from right common iliac artery to common femoral artery) and femoropopliteal [from superficial femoral artery (SFA) to popliteal artery] TASC D lesions. The iliac lesion was successfully treated with implantation of two nitinol stents. However, because of severe calcification, the SFA lesion could not be crossed with an antegrade approach alone and a retrograde approach from the high anterior tibial artery was, therefore, added. After wire crossing, the SFA lesion was stented directly followed by balloon dilation. Five months after endovascular treatment, the ulcer had healed completely thereby avoiding major amputation.