Enrichment of Y-chromosome-bearing bull spermatozoa by swim-up through a column

Reprod Domest Anim. 2014 Feb;49(1):e1-4. doi: 10.1111/rda.12252. Epub 2013 Nov 6.

Abstract

With the advancement of assisted reproductive biotechnologies, preselecting the sex of offspring has become an important goal for cattle and other livestock breeding as well as for research. The aim of this study was to investigate the feasibility of producing enriched pools of X- or Y-chromosome-bearing sperm by vertical swim-up through a long, narrow column. Sperm recovered from the top portion of the column was predominantly Y-bearing (60%, p < 0.05), which were capable of fertilizing matured oocytes and produce significantly more male embryos compared with standard swim-up protocol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle*
  • Cell Separation / methods
  • Cell Separation / veterinary*
  • Fertilization in Vitro / methods
  • Fertilization in Vitro / veterinary
  • In Situ Hybridization, Fluorescence / veterinary
  • Male
  • Sex Preselection / methods
  • Sex Preselection / veterinary*
  • Sperm Motility*
  • Spermatozoa / cytology*