Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

Chem Commun (Camb). 2014 Feb 28;50(17):2196-8. doi: 10.1039/c3cc49063g. Epub 2014 Jan 16.

Abstract

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemical synthesis
  • Acetals / chemistry*
  • Acids / chemistry*
  • Catalysis
  • Coordination Complexes / chemistry
  • Crystallography, X-Ray
  • Metals / chemistry*
  • Molecular Conformation
  • Rhodium / chemistry
  • Stereoisomerism

Substances

  • Acetals
  • Acids
  • Coordination Complexes
  • Metals
  • Rhodium