Abstract
The contractile response to substance P in-vitro is greater in strips of guinea-pig bladder freed of mucosa than in normal strips, while the response to field stimulation, histamine or KCl is unaffected by the presence of mucosa. Substance P has no inhibitory effect on histamine-induced contractions of the guinea-pig bladder. These findings support the possibility that the presence of mucosa may reduce accessibility of substance P to the muscle layer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Electric Stimulation
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Guinea Pigs
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In Vitro Techniques
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Male
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Mucous Membrane / physiology*
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects*
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Potassium Chloride / pharmacology
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Receptors, Neurotransmitter / metabolism
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Receptors, Tachykinin
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Substance P / pharmacology*
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Urinary Bladder / drug effects
Substances
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Receptors, Neurotransmitter
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Receptors, Tachykinin
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Substance P
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Potassium Chloride