This article deals with modern concepts of H. pylori infection and its role in the development of gastric and extragastic pathology. The currently available algorithms of diagnostics and treatment of this infection are presented Recommendations of recent Maastricht consensuses (7MC-3, 2005; MC-4, 2010) on diagnostics and treatment of H. pylori infection are considered. The data on resistance of H .pylori to antibiotics, mechanisms of its development and methods of control are summarized.